Key publications

Air pollutantsHousehold chemicalsFood additivesMonosodium GlutamateMicroplasticsNanoparticlesSDS/SLSGlobal warmingCOVID-19ReviewsEAACI Position PapersArticles on Allergic DiseasesArticles on Skin Diseases

Air pollutants

Desert dust and respiratory diseases: Further insights into the epithelial barrier hypothesis
May 27, 2022
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Acute respiratory barrier disruption by ozone exposure in mice
September 13, 2019
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Particulate matter 2.5 causes deficiency in barrier integrity in human nasal epithelial cells.
August 30, 2019
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Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33
January 10, 2018
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Household chemicals

Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells
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Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
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Detergent-induced eosinophilic inflammation in the esophagus: a key evidence for the epithelial barrier theory.
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Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s.
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Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin
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Food additives

Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80
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Monosodium Glutamate

Metabolism and functions of L-glutamate in the epithelial cells of the small and large intestines.
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Effects of vincristine and monosodium glutamate on gastrointestinal motility and visceral sensitivity.
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Progressive depletion of rough endoplasmic reticulum in epithelial cells of the small intestine in monosodium glutamate mice model of obesity
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Protective effect of GIP against monosodium glutamate-induced ferroptosis in mouse hippocampal HT-22 Cells through the MAPK signaling pathway
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Neuroprotective Potential of Tannic Acid Against Neurotoxic Outputs of Monosodium Glutamate in Rat Cerebral Cortex
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Evidence of alterations in brain structure and antioxidant status following ‘low-dose’monosodium glutamate ingestion
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The Effect of Monosodium Glutamate on Neuronal Signaling Molecules in the Hippocampus and the Neuroprotective Effects of Omega-3 Fatty Acids
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Does monosodium glutamate really cause headache?: a systematic review of human studies
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Protective effects of α-tocopherol against oxidative stress related to nephrotoxicity by monosodium glutamate in rats
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Effect of vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats
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The effect of vitamin C administration on monosodium glutamate induced liver injury. An experimental study
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Histochemical studies of the effects of monosodium glutamate on the liver of adult Wistar rats
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Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity
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Neonatal monosodium glutamate administration increases aminooxyacetic acid (AOA) susceptibility effects in adult mice
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A dietary restriction influences the progression but not the initiation of MSG-induced nonalcoholic steatohepatitis
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Nutrigenomics of hepatic steatosis in a feline model: effect of monosodium glutamate, fructose, and Trans-fat feeding
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Association of monosodium glutamate intake with overweight in Chinese adults: the INTERMAP Study
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Effects of oral monosodium (L)‐glutamate on insulin secretion and glucose tolerance in healthy volunteers
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Excitotoxicity triggered by neonatal monosodium glutamate treatment and blood–brain barrier function
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Monosodium glutamate in a type 2 diabetes context: A large scoping review
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The interplay between monosodium glutamate (MSG) consumption and metabolic disorders
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A review of the alleged health hazards of monosodium glutamate." Comprehensive reviews in food science and food safety
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“Extensive use of monosodium glutamate: A threat to public health?.” EXCLI journal 17 (2018): 273.
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Microplastics

Characterization and regulation of microplastic pollution for protecting planetary and human health.
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Nanoparticles

Nanoparticle-coupled topical methotrexate can normalize immune responses and induce tissue remodeling in psoriasis.
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SDS/SLS

Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1
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Double blind randomized repetitive efficacy test of various occupational skin protection preparations against sodium lauryl sulphate
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Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy
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The effect of prolonged exposure on sodium dodecyl sulfate penetration into human skin
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Study of the protective effects of cosmetic ingredients on the skin barrier, based on the expression of barrier-related genes and cytokines
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Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema-prone skin
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kin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice
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Effects of impermeable and semipermeable glove materials on resolution of inflammation and epidermal barrier impairment after experimental skin irritation
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Systematic investigation of factors, such as the impact of emulsifiers, which influence the measurement of skin barrier integrity by in-vitro trans-epidermal water loss (TEWL)
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Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s
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Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin
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Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus
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Penetration rates into the stratum corneum layer: A novel quantitative indicator for assessing skin barrier function
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Global warming

How does global warming contribute to disorders originating from an impaired epithelial barrier?
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COVID-19

Disrupted epithelial permeability as a predictor of severe COVID-19 development
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Reviews

Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs
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The epithelial barrier theory and its associated diseases
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Epithelial barrier theory in the context of nutrition and environmental exposure in athletes
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Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases
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Recent advances in the epithelial barrier theory
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The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
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The epithelial barrier theory: Development and exacerbation of allergic and chronic inflammatory diseases
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Epithelial Barrier Hypothesis and Its Comparison with the Hygiene Hypothesis
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Effect of altered human exposome on the skin and mucosal epithelial barrier integrity
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The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis
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Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma
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The epithelial barrier hypothesis proposes a comprehensive understanding of the origins of allergic and other chronic noncommunicable diseases
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Dysregulation of the epithelial barrier by environmental and other exogenous factors
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Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
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Environmental factors in epithelial barrier dysfunction
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Outside-in hypothesis revisited: The role of microbial, epithelial, and immune interactions.
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EAACI Position Papers

Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper
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Articles on Allergic Diseases

Differentiation of bronchial epithelial spheroids in the presence of IL-13 recapitulates characteristic features of asthmatic airway epithelia
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The cannabinoid WIN55212-2 restores rhinovirus-induced epithelial barrier disruption
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Inhibition of CpG methylation improves the barrier integrity of bronchial epithelial cells in asthma
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Blocking histone deacetylase activity as a novel target for epithelial barrier defects in patients with allergic rhinitis
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Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients
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Transforming growth factor-β1 decreases epithelial tight junction integrity in chronic rhinosinusitis with nasal polyps
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Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis
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Respiratory syncytial virus infection influences tight junction integrity
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Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease
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Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients
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Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression
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CpG-DNA enhances the tight junction integrity of the bronchial epithelial cell barrier
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Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-γ and IL-4
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Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects
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Allergy and hypersensitivity: Mechanisms of allergic disease
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Articles on Skin Diseases

Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin
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Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis
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Direct assessment of skin epithelial barrier by electrical impedance spectroscopy
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The IgE-reactive autoantigen Hom s 2 induces damage of respiratory epithelial cells and keratinocytes via induction of IFN-gamma
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